{"product_id":"large-molecule-pbpk-tmdd-team","title":"Large Molecule PBPK \u0026 TMDD (Team)","description":"\u003cspan data-mce-fragment=\"1\"\u003eYou will learn how to set up a simulation for large molecules (proteins and peptides) in PK-Sim. The modeled compound is an antibody-drug conjugate (ADC) applied for the treatment of prostate cancer. The ADC consists of an antibody against the transmembrane protein TenB2 (TMEFF2) and the antimitotic toxin monomethyl auristatin E (MMAE), which is attached to the antibody by a linker. The antibody in the ADC has high affinity to the TMEFF2 receptor making it a suitable substance to target prostate cancer cells over-expressing TMEFF2, while the MMAE toxin is used to neutralize\/kill such cancer cells.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eYou will set up a combined model for the simulation of the ADC and the released toxophore (i.e. the MMAE toxin) including receptor dynamics and internalization of the ADC-receptor complex. Here, you will learn how to:\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e1. export a PK-Sim model to MoBi.\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e2. integrate the reactions for receptor dynamics and internalization of the ADC-TMEFF2 complex (import “ReactionsADCModel.pkml).\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e4. simulate and analyze the behavior of the toxophore concentration in venous blood and the TMEFF2 concentration in the interstitium of the lung for different doses\u003c\/span\u003e\u003cbr data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e5. investigate how naked antibodies change the result.\u003c\/span\u003e","brand":"OSP-Suite Version 12","offers":[{"title":"Default Title","offer_id":56334258274635,"sku":null,"price":400.0,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0549\/1779\/1804\/files\/Thumbnails_3_9a7ede0b-3142-4995-980b-ddc190d55f4d.png?v=1763473085","url":"https:\/\/shop.esqlabs.com\/products\/large-molecule-pbpk-tmdd-team","provider":"ESQlabs GmbH","version":"1.0","type":"link"}