Satellite Workshop QSPC - Building Scalable PBPK-QSP Models

OSP-Suite/Event

April 07, 2026

9:00 am - 5:00 pm

Building Scalable PBPK-QSP Models: Modularization in MoBi for OSP Suite V12

If you plan to join the Quantitative Systems Pharmacology Conference 26 in Leiden, don't miss our Satellite Workshop!

The latest OSP Suite V12 introduces a revolutionary modularization approach that significantly enhances the flexibility, scalability, and efficiency of quantitative systems pharmacology (QSP) modeling and integrations with physiologically-based PK (PBPK-QSP). This full-day hands-on workshop will equip participants with the skills to leverage modular workflows in MoBi to build, extend, and refine PBPK-QSP models like never before.

During this workshop, attendees will start with a simple two-compartment model to grasp the fundamentals of modularization before diving into a real-world case study: modeling an ADC modality for tumor treatment. Participants will:

Develop a PBPK model for the large molecule and small molecule payload.
Modularization 1: adding a Target-Mediated Drug Disposition reaction network as a reaction extension module.
Modularization 2: adding a tumor organ as a physiological extension module.
Modularization 3: Implement a pharmacodynamic effect extension module to simulate tumor growth inhibition.
Work with separate modules to demonstrate how modular workflows streamline model management, reuse, and extension.

By the end of the workshop, attendees will master the new modular approach in MoBi, learning how to efficiently build and manage complex models in a structured way. While automated model qualification will be touched upon as an outlook, the focus will be on hands-on modeling and modularization techniques that enhance collaboration, transparency, and reusability in PBPK-QSP modeling.

Agenda Highlights:

Understanding modularization in OSP Suite V12
Adding new organs to PBPK models seamlessly
Developing effect models as independent modules
Modeling tumor treatment and large molecules with modular PBPK-QSP workflows

Who Should Attend?

This workshop is ideal for PBPK/QSP modelers, clinical pharmacologists, and researchers looking to enhance their mechanistic modeling workflows using the latest innovations in MoBi and OSP Suite V12. Whether you're new to OSP Suite or an experienced user, you'll leave with practical skills to create modular, scalable, and reusable models for drug development and translational research.